http://opentox.org/dev/apis/api-1.2/Ontology

• Query : can be sent by GET or POST, according to http://www.w3.org/TR/rdf-sparql-protocol/, or more specific the HTTP Binding

   curl -X POST -H "Content-type:application/x-www-form-urlencoded" \
           -d "query=the-sparql-query-url-encoded" https://apps.ideaconsult.net/ontology \
           -H "Accept:application/rdf+xml"  -H "subjectid:SECURITY-TOKEN 
  

• Resource registration - send via POST of a web form, with a field uri, containing the uri of the registered resource. The resource should return application/rdf+xml representation, otherwise it will not be registered. The security token is optional (depending on whether the resource is protected).

        curl -X POST -d "uri=http://host2:8080/ambit2/dataset/1" http://host1:8080/ontology \
                 -H "subjectid:SECURITY-TOKEN"
  

Results are returned in several formats, depending on the HTTP Accept header.

• application/sparql-results+xml
• text/html
• text/n3
• text/csv
• text/plain

• Example 1. Retrieve list of features, representing Estrogen receptor gene assay from ToxCast Phase 1 datasets:

  We will be using the predefined SPARQL query at https://ambit.uni-plovdiv.bg:8443/ontology/query/ToxCast_ESR1

   curl -H "Accept:text/plain" https://ambit.uni-plovdiv.bg:8443/ontology/query/ToxCast_ESR1
  
   ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
   | Feature                                                 | title           | OpentoxDataset                                          | assay                 | genename     |
   ==============================================================================================================================================================================
   | <https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2643> | "NVS_NR_hER"    | <https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/4563> | toxcast:NVS_NR_hER    | toxcast:ESR1 |
   | <https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2285> | "ATG_ERE_CIS"   | <https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/723>  | toxcast:ATG_ERE_CIS   | toxcast:ESR1 |
   | <https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2214> | "ATG_ERa_TRANS" | <https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/723>  | toxcast:ATG_ERa_TRANS | toxcast:ESR1 |
   ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
   
  

  There is one assay NVS_NR_hER from Novascreen ToxCast assays and two (ATG_ERE_CIS,ATG_ERa_TRANS) from Attagene ToxCast assays.

  The predefined SPARQL query looks like is as follows:

   PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
   PREFIX rdf:<http://www.w3.org/1999/02/22-rdf-syntax-ns#>
   PREFIX owl:<http://www.w3.org/2002/07/owl#>
   PREFIX dc:<http://purl.org/dc/elements/1.1/>
   PREFIX ot:<http://www.opentox.org/api/1.1#>
   PREFIX toxcast:<http://www.opentox.org/toxcast#>
   select ?Feature ?title ?OpentoxDataset ?assay ?genename
          where {
              ?Feature rdf:type ot:Feature.
         {?Feature ot:hasSource ?OpentoxDataset}.
             {?Feature dc:title ?title}.
             {?Feature owl:sameAs ?assay}.
             {?assay toxcast:gene <http://bio2rdf.org/geneid:2099>}.
             {?assay toxcast:hasProperty ?genename}.
             {?genename rdf:type toxcast:GENE_NAME}.
          }
  

  Once we know which features are representing the Estrogen receptor related studies, the three columns can be collated with the ToxCast dataset and data retrieved in various formats.

   curl -H "Accept:chemical/x-mdl-sdfile" https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/37?feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2643&feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2285&feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2214
   
   curl -H "Accept:text/n3" https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/37?feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2643&feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2285&feature_uris[]=https://ambit.uni-plovdiv.bg:8443/ambit2/feature/2214
  
  

  Collating with columns from https://ambit.uni-plovdiv.bg:8443/ambit2/dataset/37 dataset gives a new dataset.

  Or it is also possible to retrieve the assay data for specific compound (e.g. Bisphenol A).